When comparing pyglet vs TIC-80, the Slant community recommends pyglet for most people. In the question“What are the best 2D game engines?” pyglet is ranked 43rd while TIC-80 is ranked 49th. The most important reason people chose pyglet is:
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Specs
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Pros
Pro 3D support
Since pyglet is so tightly woven with OpenGL it allows the support of drawing in 3D.
Pro Cross-platform
Works with Windows, Linux, and OS X.
Pro Written in pure Python
A small advantage, but being a core Python developer, it may be the best to stick to the roots and develop with pyglet as it is able to compile using other Python interpreters.
Pro All tools in one place
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Pro Free
Free version already includes most features but a paid version is available.
Pro Retro-styled and restricted environment
Pixelated Software with a good retro style.
Pro Many Scripting languages' supported
Use awesome scripting languages like: Lua, Wren, Moonscript, JS, Ruby, etc.
Pro Export
Exports easily to Windows, Windows-XP, mac, Linux and HTML.
Pro Noob underdog
You can imagine this engine Shiva Lua scripting language making 2d side scrolling Megaman style games a Bandai trademark.
Cons
Con Small community/popularity
There is a decent amount of documentation and API to go along with pyglet, but in terms of community support there seems to be very little.