When comparing Keynote vs Microsoft PowerPoint, the Slant community recommends Microsoft PowerPoint for most people. In the question“What are the best mockup and wireframing tools for websites?” Microsoft PowerPoint is ranked 22nd while Keynote is ranked 24th. The most important reason people chose Microsoft PowerPoint is:
Because PowerPoint is so common, there are tons of free templates found within the program or online.
Specs
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Pros
Pro Imports nearly every type of asset
Can import all kinds of assets (images, videos, PDFs, sounds) into mockup without hassle.
Pro Animations and transitions
Keynote currently is one of the very few tools that supports animation of elements and transition of views without programming.
Pro Text Styles makes it easy to create typography systems
Pro Smart Snaps
Keynote has alignment grids (aka snap to grid feature) that snaps to end, midpoints, baselines etc of objects and grids. They are super useful when you want to follow a structured layout for your wireframe.
Pro Lots of free templates
Because PowerPoint is so common, there are tons of free templates found within the program or online.
Pro De facto standard
PowerPoint is the most widely used presentation app.
Pro Excellent integration with Windows
Cons
Con Only available on Mac and it's file are not compatible with Microsoft Windows
Con Is poor at handling animation-heavy presentations
Adding too many animations might cause it to slow down quite significantly, as well as on older versions more complicated animations might not work very well.