When comparing TweetDark vs Tweetbot, the Slant community recommends Tweetbot for most people. In the question“What are the best Twitter clients for OSX?” Tweetbot is ranked 1st while TweetDark is ranked 3rd.
Ranked in these QuestionsQuestion Ranking
Pro Multiple account support
Allows easy switching of accounts withing the app.
Pro Works also as a Facebook & FourSquare app
TweetDark combines Twitter, Facebook & FourSquare in one app.
Pro Beautiful design
Pro Multiple accounts
Manage multiple accounts and get alerts for them
Pro Excellent search features
Type your search term, then select whether you want to search for tweets that contain that term or go straight to the user whose name is the same as your search term.
Pro Keyboard shortcuts
cmd+n, shift+cmd+enter -- pretty much every time I've thought "maybe this is the shortcut for that" I've been right. Super intuitive.
Free version has ads that can be removed by buying $5 premium version.