Ranked in these QuestionsQuestion Ranking
Pro It's Python
It's not just python-like - it is python, and as such can use a ton of handy python modules from the internet to do strange and outlandish things. Being able to leverage your existing python skills is super handy.
Pro Good docs and active forum
Con It's Python
If you do not know Python or are not interested in coding or learning it, this is wholly unsuited for you. That's cool - it takes all kinds, and there are good alternatives available for you.
Con Not primarily intended as an automation app
Pythonista is a general programming app; it can do automation, and do it well, but automation is not the primary focus of the app or it's users, and so it takes some digging to find the bits you need related to automation. I see this as a plus for the app in and of itself, but many will find an app that is focused on automation to be more useful for their needs.