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Pros
Pro Allows mixed airlines on the same flight
Pro Supports complex search queries
It's possible to search flights with queries like 'Depart from within either 250 km of Manchester, or from France, leaving on a Friday night during the summer, flying to anywhere (the cheapest destination) reachable with a direct flight, and return after 3 to 5 nights'.
Cons
Con Poor customer support
Online chat never seams to be available and almost always on hold when calling support.