What is the best alternative to Topcoat?
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PostCSS allows you to opt-in to the features you need with plugins. This allows you to set it up to behave exactly like Sass, with nesting, mixing, extends, and more. On the other hand, it allows you to use plugins by themselves for things like auto-prefixing, minification, and more. You can even set up your own custom "stack" of plugins to do exactly what you like. See More
UiKit is not a very popular framework, especially compared to other options. As such it may be hard to find learning resources other than the official documentation or it may be more likely for development of UiKit to be dropped than for another more popular framework See More
Bootstrap's over-reliance on HTML classes for styling can get very messy very quickly. There's also an overabundance of DOM elements which have a lot of classes and are more often than not nested inside DOM elements with even more classes. This gets problematic down the line because the maintainability of the project gets harder when the project starts to get large. See More