Pydoctor was created to replace Epydoc for more improvement. An API documentation generator that works by static analysis.
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Pros
Pro Created for improvement
Pydoctor was created to improve more from Epydoc. So it is even more better that Epydoc. For the purposes of the Twisted project as epydoc has difficulties with zope.interface. Puts a fair bit of effort into resolving imports and computing inheritance hierarchies and, as it aims at documenting Twisted, knows about zope.interface's declaration API and can present information about which classes implement which interface, and vice versa.
Pro Output can be pass to Sphinx
PyDoctor can pass object model to Sphinx to output style same as Sphinx. So from Pydoctor you could still pass the object model to Sphinx if you still prefer Sphinx look.
Pro Outstanding clean look
Pydoctor has more neat look compared to other documentation generator.
Cons
Con Poor documentation and small size of community
Documentation is little and there isn't too much about Pydoctor references. Unlike Sphinx or any other documentation generators.