SkyUI is a complete overhaul of the menu system optimized for PC inputs.
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Pros
Pro Icons in items list helps to find a specific item by type
Pro Better quick menu
One of the best enhancements to gameplay SkyUI provides is several advanced features for the quick menu. You can now assign items to number hotkeys to quickly swap out items without pulling up the menu, and even create item sets to be able to completely swap out all your equipped items instantly with up to 8 different sets. This completely changes how you play the game as it's now feasible to have multiple item sets for different play style, such as instantly switching out from warrior armor to sneak clothes.
Pro Value/Weight column
There's an option to show value/weight so you can determine what to drop when you're over-encumbered.
Pro Searching
You can press space, or click on the search field in the top right to do a text search to find items quicker.
Pro Better hotkeys
You can easily switch between your inventory and the merchant inventory by pressing alt, instead of having to navigate up and down a list, this also allows you to swap between you and the merchant while maintaining the category you are looking at.
Pro Sortable tables
Items are now sortable by name, type, weight, and value, making it much much easier to find what you're looking for, and manage your inventory.