The game allows for players to easily hide in plain sight through a disguise system, like dressing up as a model at a fashion show, which gives the player access to anywhere they might want to go. This is expanded upon by having a helpful hint system for those who are unfamiliar with its intricacies.

More so than previous games in the series, Hitman has many objects that can be tampered or interacted with. Nearly any problem the player faces can be solved by using the game's many interactive objects. For players unsure where to start, the challenge system offers a wide variety of hints. For instance, the optional challenges for the first training level include one where the player must disguise himself as a special character who is scheduled to meet the target and another where the target can be given rat poison at the bar.

Once the main level and objective is complete, players can move on to escalation missions or player-created contracts. Escalation missions remix the maps, giving players new targets to complete in the same maps. Paris features 17 escalations, Sapienza has 9, and the other missions have some as well. More are being added all the time. Escalations are unusual in that they feature specific constraints, such as specific uniforms that must be worn, or specific methods of assassination. This increases the difficulty, but it's a great to expand each episode. The player contracts are similar, but this game mode allows the player to choose who their target is and what constraints to put in place, making for an endless list of possibilities in a particular level. Each level also features 20 'Mastery' levels, which unlock tools and insertion locations that expand the way the level can be played. Hitman is a game built to be replayed.

The game's six levels are all big sandboxes that allow players to complete their tasks in any way they see fit. This allows players a great deal of freedom in experimentation and the customization of play style. One of the earliest assassinations in the game can be achieved through the manipulation of a chess board, sabotaging the ejection seat of a fighter jet, or faking a radio call, among other things. Hitman provides a strong context for the player's actions, but there is no wrong way to play, so long as you get the target.