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Textual is the world's most popular application for interacting with Internet Relay Chat (IRC) chatrooms on OS X.
Lime chat is a basic IRC client for Mac
#4 Linkinus 2
Linkinus 2 is a commercial IRC client meant to be for a "rich social experience."
Irssi is a terminal based IRC client for UNIX systems. It also supports SILC and ICB protocols via plugins. Irssi is also available on OS X via homebrew.
WeeChat is a fast, light and extensible chat client. It runs on many platforms, is modular, can support other protocols, is scriptable in 6 languages, fully-documented both in and
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