Pro Full Control Of Sprites
DAME allows you full control over each individual sprite. For example, you can draw directly on each sprite to make it unique. It even goes detailed enough to let you choose which frame an animated spite starts on.
In addition, DAME has a "Sprite Trail" feature that makes it easy to draw a series of sprites on the map any way you wish. This is especially useful when placing things like coins.
Pro "Matrix" Tool
DAME comes with a matrix tool that allows you to create a custom matrix of tiles that you can then use to paint varying sizes of that grid onto your map. It also allows you to randomize the tiles in the center of the grid making this a great tool for creating backgrounds.