The documentation for the toolkit is well written and there are video tutorials as well as an active community.
Pixel games in the style of 8 or 16 bit systems need to have each pixel uniform on the screen which 2D Toolkit supports with a camera component.
2D Toolkit allows for different sizes of atlas from 1x, 2x, or 4x which can be changed depending on platform resolution.
Choose from either a box, sphere, or mesh collider that will output as either a 3D or 2D collider in Unity.
Although a great solution for sprite sheet animations 2D Toolkit does not natively support skeletal based animation.
2D Toolkit provides a completely proprietary sprite implementation. Though it can be used alongside Unity's 2D systems, the two are completely separate and require different code to utilize.