It's possible to leave WeeChat running at home/on a server, then connect to it with a smartphone client. This way a choppy mobile internet connection won't disconnect from IRC, and still allow using a touch screen optimized UI.
By default WeeChat has a chat area surrounded by a nicklist on the right, title bar on top, and status and input bars at the bottom. The layout, though, can be completely customized and split vertically or horizontally. It supports 256 colors as long as the terminal supports 256 colors as well as bolded, italicized and underlined text. Even includes little touches as differently colored nicknames for people /away.
While there are some unofficial remote graphical interfaces available for WeeChat, it is intended to be used as a terminal client. As such it might be challenging to use to those accustomed to graphical interfaces.