Recs.
Updated
SpecsUpdate
Pros
Pro Powerups combine in very unique ways
There are tons of unique power ups, and most of them interact with each other to create really interesting combinations. The main attack in the game is shooting a projectile, and modifiers on top of that stack making for really interesting attacks. For example, you can have a homing, multi, laser attack that shoots in both directions by combining multiple treasures. You can build really interesting strategies this way and that keeps the game feeling fresh.
Pro Incredible amount of content
The Binding of Isaac: Rebirth has all of the original games content as well as many new add ons such as the Wrath of the Lamb expansion as well as many extra characters.
Lots of characters each with their own unique starting abilities, plus many challenges gives the game really high replay value.