Pro Excellent autofocus
D500 has 153 AF points of which you can select 55. 99 AF points are cross-type (of which 35 are selectable). 15 AF points work with f/8 lenses (of which 9 are selectable). The autofocus works down to LV -4.
Autofocus is fast at 10 frames per second with great accuracy - in autofocus tests performed by Tony Northrup the D500 trailed D5 just slightly by getting 16% fewer of shots in focus and 1DX Mark II by about 18%.
Con Video has a 2.2x 35mm-equivalent crop factor
The camera has a 1.5x 35mm-equivalent crop factor and shooting video adds another 1.5x crop factor on top of that resulting in a 2.2x 35mm-equivalent crop factor. The effective sensor size is near the size of a MFT sensor. That means you would need wider lenses to achieve the same result in each situation.