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Pi-hole is a great solution that can be applied to your entire LAN instead of futzing around with various browser or OS-based blockers. It's especially convenient if you're using a variety of browsers on a variety of platforms and don't have time to ensure all the blockers are always up-to-date.
Pi-Hole is positioned between your network and your DNS server which is normally your router or the ISP modem. All DNS requests for the net are first passed through pi-hole and blacklisted sites are purged/blocked. Whitelisted or sites that aren't black-listed, pass back to your router for resolution by your ISP or your named DNS provider.
Best of all, you can add this to your LAN on a $35 Raspberry PI and immediately enable ad-blocking for every device on your network!