When comparing pygame vs Leadwerks Game Engine, the Slant community recommends pygame for most people. In the question“What are the best 2D game engines?” pygame is ranked 16th while Leadwerks Game Engine is ranked 75th. The most important reason people chose pygame is:
Pygame uses Python as its scripting language. Python is widely considered one of the easiest languages to grasp even for beginners.
Specs
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Pros

Pro Easy Python syntax
Pygame uses Python as its scripting language. Python is widely considered one of the easiest languages to grasp even for beginners.
Pro Very easy to understand
The API is very straightforward.
Pro Good canvas system
Pygame has a drawing system that allows the user to create and draw on an unlimited number of canvases.

Pro Versatile flow diagram script model
Leadwerks's flowgraphs resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.
Pro Built-in level editor
Has an acceptable 3D map editor that is easy to use.
Pro Handful of Prefabs and Scripts
For example, you take a model (e.g. torch), add a light source to it, add a particle generator (for fire) and save it as a prefab (one file). Then this prefab can be used to add many torches with fire and light.
Cons

Con Deathly slow
Con Nonexistent community
No good forums, wiki, or other ways to reach other Pygame developers.
Con Very basic
Pretty much just a wrapper for SDL.
Con Pygame is a multimedia framework, not a game engine
Physics, AI and networking are not supported.
Con Messy documentation
The docs are messy, and some basic functions are infuriating to work out. There's even some places in the documentation where it's clearly wrong about how a method is called/what the arguments really do.
Con Outdated
Pygame uses a really old version of SDL and is missing some of the features developed for SDL2.
Con Hasn't been updated in years
Hasn't been updated in years.
Con Very buggy
Leadworks is a not complete, it's a work in progress. As such many parts of the engine are clunky, especially the level editor.

Con Documentation and support are limited for non-coders
The flowgraph editor can be used with free script assets to build games without writing any code, but this is not directly intended or encouraged by Leadwerks.
Con Highly misleading advertising
