When comparing pygame vs Pixi.js, the Slant community recommends pygame for most people. In the question“What are the best 2D game engines?” pygame is ranked 16th while Pixi.js is ranked 56th. The most important reason people chose pygame is:
Pygame uses Python as its scripting language. Python is widely considered one of the easiest languages to grasp even for beginners.
Specs
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Pros

Pro Easy Python syntax
Pygame uses Python as its scripting language. Python is widely considered one of the easiest languages to grasp even for beginners.
Pro Very easy to understand
The API is very straightforward.
Pro Good canvas system
Pygame has a drawing system that allows the user to create and draw on an unlimited number of canvases.
Pro Supports WebGL w/ canvas fallback
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
Pro Will be familiar to ActionScript developers
Pixi.js uses a code structure that's very similar to ActionScript.
Cons

Con Deathly slow
Con Nonexistent community
No good forums, wiki, or other ways to reach other Pygame developers.
Con Very basic
Pretty much just a wrapper for SDL.
Con Pygame is a multimedia framework, not a game engine
Physics, AI and networking are not supported.
Con Messy documentation
The docs are messy, and some basic functions are infuriating to work out. There's even some places in the documentation where it's clearly wrong about how a method is called/what the arguments really do.
Con Outdated
Pygame uses a really old version of SDL and is missing some of the features developed for SDL2.
Con Hasn't been updated in years
Hasn't been updated in years.
Con Not a complete solution
Pixi only provides the renderer.
