When comparing Loom SDK vs Ren'Py, the Slant community recommends Ren'Py for most people. In the question“What are the best 2D game engines?” Ren'Py is ranked 39th while Loom SDK is ranked 45th. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Live reload of code and assets across multiple platforms
Loom can live update changes in realtime, allowing you to see them on multiple devices immediately.
Pro Powerful command line workflow
Loom Turbo ($5/mo) gives access to powerful command line tools. For example, "loom new" to make a new project, "loom run" to run it. Packaging, deploy, and live reload are done automatically for you.
Pro Open source
The Loom runtime and LoomScript compiler are open source, with code available on GitHub, allowing you to have the freedom to fix the bugs and add the features your game needs.
Pro Examples
Loom includes over 30 examples ranging from complete sample games to demos of single features.
Pro Familiar and powerful scripting
Loom's scripting language is immediately familiar if you know JavaScript, ActionScript, TypeScript, C#, or Java. Internally, it uses a proven VM technology with over 10 years of heavy use in games.
Pro Good support
Loom devs are helpful.
Pro Cross-platform
Loom can deploy to Windows, OS X, Linux, iOS, Android (including Nook, Kindle Fire and Ouya). There are also custom port available for WP8, Blackberry and consoles.
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games
Cons
Con Documentation is lacking
Con No visual tools support
There's no level editor, asset viewer or any other visual tools in Loom SDK. Everything has to go through command line. I think it's fine if you really like typing.
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.