When comparing Codea vs Ren'Py, the Slant community recommends Ren'Py for most people. In the question“What are the best 2D game engines?” Ren'Py is ranked 39th while Codea is ranked 107th. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Helpful code editor
Errors show up live, as you type. Smarter autocompletion picks up your local and global variables, including nested types. Everything else is just plain smarter, from indentation to highlighting.
Pro Ships with music and sound packs
Codea ships with three great music and sound packs, composed just for Codea and free for you to use in whatever you create.
Pro You can code on an iPad and easily distribute the game
Pro Location library
Location library lets you make use of the GPS inside your iPad. Get your latitude, longitude, altitude and more with a dead-simple API designed specifically for Codea.
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games
Cons
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.