When comparing Duality vs Microsoft XNA Game Studio, the Slant community recommends Duality for most people. In the question“What are the best 2D game engines?” Duality is ranked 30th while Microsoft XNA Game Studio is ranked 80th. The most important reason people chose Duality is:
The full source code is available on GitHub, where the framework is actively developed. All of the editor, core and plugin code is written in C#.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Open source
The full source code is available on GitHub, where the framework is actively developed. All of the editor, core and plugin code is written in C#.

Pro Great editor
Duality includes a powerful visual editing system that can be used for previewing, integrating, editing and testing game content.

Pro Live reload of code and assets

Pro Very extensible
Because both Core and Editor are completely plugin-based, Duality not only incorporates a clean and modular design, but is also very extensible - even if it wasn't Open Source. In fact, most of the standard editing capabilities comes in form of Editor plugins.

Pro Built-in physics and lighting

Pro Friendly to version control systems
It can be configured to serialize all data in a text-based format, which has been structurally optimized for version control systems.

Pro Used in commercial projects
It has been used in a production environment without burning the place to the ground. Supposedly artist-proof editor workflow with an API for tailoring the system to fit your team.

Pro Easy assets
it is very easy to import your own 2 dimensional assets

Pro Very easy to use
relies largely on drag and drop elements and has been used to create notable high quality 2d games such as DLC Quest
Cons
Con Visual Studio required
To have possibility for scripting you have to download entire Visual Studio and spend 10 GB of free space
Con Requires windows for development

Con It's dead
It is not getting updated and Microsoft does not recommend using it anymore.

Con Limited platform support
Only supports Xbox 360, Windows and Windows Phone
