When comparing Duality vs Genome2D, the Slant community recommends Duality for most people. In the question“What are the best 2D game engines?” Duality is ranked 30th while Genome2D is ranked 47th. The most important reason people chose Duality is:
The full source code is available on GitHub, where the framework is actively developed. All of the editor, core and plugin code is written in C#.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Open source
The full source code is available on GitHub, where the framework is actively developed. All of the editor, core and plugin code is written in C#.

Pro Great editor
Duality includes a powerful visual editing system that can be used for previewing, integrating, editing and testing game content.

Pro Live reload of code and assets

Pro Very extensible
Because both Core and Editor are completely plugin-based, Duality not only incorporates a clean and modular design, but is also very extensible - even if it wasn't Open Source. In fact, most of the standard editing capabilities comes in form of Editor plugins.

Pro Built-in physics and lighting

Pro Friendly to version control systems
It can be configured to serialize all data in a text-based format, which has been structurally optimized for version control systems.

Pro Used in commercial projects
It has been used in a production environment without burning the place to the ground. Supposedly artist-proof editor workflow with an API for tailoring the system to fit your team.

Pro Lightning fast
It's the fastest gpu-based framework out there for flash. It's beautifully optimised. It has very low rendering latency, low level OpenGL calls that other tech simply cannot do (ie Unity) due to Stage3D, and thus can render a lot more data quicker
Pro Cross-platform mobile, desktop and web
Supports Windows, Mac OS X, Linux, iOS, Android, Web and native Flash.
And with the HTML5 export, it also potentially supports development for the Wii U :)
Pro Haxe!
Haxe is a strictly typed programming language that saves development time but still compiles high performance executables, and can build for tons of different platforms (flash, c++, html5, java, c#, etc.)
Pro Access to direct draw features
Has access to direct draw features so you can make you own rendering structures (scene graphs etc).
Pro Automatic dynamic batching
Automatically batch geometries with dynamic batching techniques (by using constant buffers).
Pro Component based architecture
Cons
Con Visual Studio required
To have possibility for scripting you have to download entire Visual Studio and spend 10 GB of free space
Con Requires windows for development
Con Lacks documentation
The API documentation is minimal, there's not many tutorials and the ones that are there are very small and only cover the basics. If you want to learn how to properly use it, you have to ask the community or read the source code and figure it out.
Con Not too many games to showcase it
Con Slow development rate
