When comparing Microsoft XNA Game Studio vs Pixi.js, the Slant community recommends Pixi.js for most people. In the question“What are the best 2D game engines?” Pixi.js is ranked 56th while Microsoft XNA Game Studio is ranked 80th. The most important reason people chose Pixi.js is:
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
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Pros

Pro Easy assets
it is very easy to import your own 2 dimensional assets

Pro Very easy to use
relies largely on drag and drop elements and has been used to create notable high quality 2d games such as DLC Quest
Pro Supports WebGL w/ canvas fallback
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
Pro Will be familiar to ActionScript developers
Pixi.js uses a code structure that's very similar to ActionScript.
Cons

Con It's dead
It is not getting updated and Microsoft does not recommend using it anymore.

Con Limited platform support
Only supports Xbox 360, Windows and Windows Phone
Con Not a complete solution
Pixi only provides the renderer.
