When comparing Microsoft XNA Game Studio vs TIC-80, the Slant community recommends TIC-80 for most people. In the question“What are the best 2D game engines?” TIC-80 is ranked 49th while Microsoft XNA Game Studio is ranked 80th. The most important reason people chose TIC-80 is:
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Easy assets
it is very easy to import your own 2 dimensional assets

Pro Very easy to use
relies largely on drag and drop elements and has been used to create notable high quality 2d games such as DLC Quest
Pro All tools in one place
The app contains tools for coding, sprite editing, map editing, sfx and music editing.
Pro Free
Free version already includes most features but a paid version is available.
Pro Retro-styled and restricted environment
Pixelated Software with a good retro style.
Pro Many Scripting languages' supported
Use awesome scripting languages like: Lua, Wren, Moonscript, JS, Ruby, etc.
Pro Export
Exports easily to Windows, Windows-XP, mac, Linux and HTML.
Pro Noob underdog
You can imagine this engine Shiva Lua scripting language making 2d side scrolling Megaman style games a Bandai trademark.
Cons

Con It's dead
It is not getting updated and Microsoft does not recommend using it anymore.

Con Limited platform support
Only supports Xbox 360, Windows and Windows Phone
