When comparing Crafty.js vs Pixi.js, the Slant community recommends Crafty.js for most people. In the question“What are the best 2D game engines?” Crafty.js is ranked 37th while Pixi.js is ranked 56th. The most important reason people chose Crafty.js is:
Easy to learn, based on Entities and Components, the later being class-like objects that entities inherit.
Specs
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Pros

Pro Eventbinding
Easy to learn, based on Entities and Components, the later being class-like objects that entities inherit.

Pro Javascript
Pro Modular
Has open function binding systems, allowing easy creation of custom components.
Pro Supports WebGL w/ canvas fallback
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
Pro Will be familiar to ActionScript developers
Pixi.js uses a code structure that's very similar to ActionScript.
Cons
Con No IDE
If you like having some huge GUI akin to Gamemaker, Unreal, Unity, etc, Crafty is not for you.
Con Not a complete solution
Pixi only provides the renderer.
