When comparing Genome2D vs Buildbox, the Slant community recommends Genome2D for most people. In the question“What are the best 2D game engines?” Genome2D is ranked 47th while Buildbox is ranked 51st. The most important reason people chose Genome2D is:
It's the fastest gpu-based framework out there for flash. It's beautifully optimised. It has very low rendering latency, low level OpenGL calls that other tech simply cannot do (ie Unity) due to Stage3D, and thus can render a lot more data quicker
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Lightning fast
It's the fastest gpu-based framework out there for flash. It's beautifully optimised. It has very low rendering latency, low level OpenGL calls that other tech simply cannot do (ie Unity) due to Stage3D, and thus can render a lot more data quicker
Pro Cross-platform mobile, desktop and web
Supports Windows, Mac OS X, Linux, iOS, Android, Web and native Flash.
And with the HTML5 export, it also potentially supports development for the Wii U :)
Pro Haxe!
Haxe is a strictly typed programming language that saves development time but still compiles high performance executables, and can build for tons of different platforms (flash, c++, html5, java, c#, etc.)
Pro Access to direct draw features
Has access to direct draw features so you can make you own rendering structures (scene graphs etc).
Pro Automatic dynamic batching
Automatically batch geometries with dynamic batching techniques (by using constant buffers).
Pro Component based architecture

Pro Drag - and - drop editor
Drag - and - drop editor without writing any line of code.
Pro Easy to learn
Buildbox is a drag and drop engine, making it easy for beginners to pick up. There are many tutorials available to help get you started.
Pro Has many game templates
Buildbox has 20+ different game templates including templates for platformers, racing games and Flappy Bird clones.
Pro Built-in support for ads
You can add banner and interstitial ads from multiple ad networks, including AdMob, RevMob, Facebook. They can work with Amazon's, Microsoft's, Google's and Apple's app stores.
Pro Develop once publish everywhere
Exporting iOS/Android/macOS/Windows/Steam/Amazon
Pro Cross-platform
Cons
Con Lacks documentation
The API documentation is minimal, there's not many tutorials and the ones that are there are very small and only cover the basics. If you want to learn how to properly use it, you have to ask the community or read the source code and figure it out.
Con Not too many games to showcase it
Con Slow development rate
Con Incredibly Expensive
$99/mo for full functionality probably makes this the least accessible piece of game development software in regards to price, all with a very limiting feature set.
Con You are restricted by it's limitations
For example, you can only make certain kind of games.
Con Not very powerful
You will be limited to using templates to build games.
Con Subscription Model
The two more reasonable price points limit the functionality of a software already far less powerful than many more cost effective alternatives.

Con Very expensive
Buildbox has a 15-day trial version, after that a $2675 license to use it must be bought.
Con Stability Issues
The software has stability issues on Windows, with the preview window causing program crashes when simple functionality is added.
