When comparing Genome2D vs Defold, the Slant community recommends Defold for most people. In the question“What are the best 2D game engines?” Defold is ranked 21st while Genome2D is ranked 47th. The most important reason people chose Defold is:
Defold uses Lua, which is regarded as an easy to learn language by most.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Lightning fast
It's the fastest gpu-based framework out there for flash. It's beautifully optimised. It has very low rendering latency, low level OpenGL calls that other tech simply cannot do (ie Unity) due to Stage3D, and thus can render a lot more data quicker
Pro Cross-platform mobile, desktop and web
Supports Windows, Mac OS X, Linux, iOS, Android, Web and native Flash.
And with the HTML5 export, it also potentially supports development for the Wii U :)
Pro Haxe!
Haxe is a strictly typed programming language that saves development time but still compiles high performance executables, and can build for tons of different platforms (flash, c++, html5, java, c#, etc.)
Pro Access to direct draw features
Has access to direct draw features so you can make you own rendering structures (scene graphs etc).
Pro Automatic dynamic batching
Automatically batch geometries with dynamic batching techniques (by using constant buffers).
Pro Component based architecture
Pro Easy to learn
Defold uses Lua, which is regarded as an easy to learn language by most.
Pro Completely free of charge
Software and online dashboard are free of charge.
Pro Good combination of visual editing + code (Lua)
You can do a lot with drag and drop, but you're not limited -- the code (Lua, which is easy to learn) allows you more power than just visual editing usually gives you.
Pro Fast results
Going from idea to result is very important for the creative process.
Pro Visual editor
Pro Very performant
Being crossplatform it is important to work on low end devices.
Pro Easy and fast export for various platforms
Pro Great community
A very active and friendly community in forums.
Pro Source code available
You can download and modify the source code of the Editor and the engine for free.
Pro Collaborative
You can invite friends from the dashboard and create games together.
Pro Hot reload
It allows you to change scripts in a game while it is running live. Common use-cases is to tweak gameplay parameters or to perform debugging on a running game.
Cons
Con Lacks documentation
The API documentation is minimal, there's not many tutorials and the ones that are there are very small and only cover the basics. If you want to learn how to properly use it, you have to ask the community or read the source code and figure it out.