When comparing Genome2D vs PureBasic, the Slant community recommends PureBasic for most people. In the question“What are the best 2D game engines?” PureBasic is ranked 40th while Genome2D is ranked 47th. The most important reason people chose PureBasic is:
Can create single file executables without the need to install other libraries, run time environments, etc.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Lightning fast
It's the fastest gpu-based framework out there for flash. It's beautifully optimised. It has very low rendering latency, low level OpenGL calls that other tech simply cannot do (ie Unity) due to Stage3D, and thus can render a lot more data quicker
Pro Cross-platform mobile, desktop and web
Supports Windows, Mac OS X, Linux, iOS, Android, Web and native Flash.
And with the HTML5 export, it also potentially supports development for the Wii U :)
Pro Haxe!
Haxe is a strictly typed programming language that saves development time but still compiles high performance executables, and can build for tons of different platforms (flash, c++, html5, java, c#, etc.)
Pro Access to direct draw features
Has access to direct draw features so you can make you own rendering structures (scene graphs etc).
Pro Automatic dynamic batching
Automatically batch geometries with dynamic batching techniques (by using constant buffers).
Pro Component based architecture
Pro Standalone executables
Can create single file executables without the need to install other libraries, run time environments, etc.
Pro The syntax is very beginner-friendly
Pro Same code on Windows, OS X and Linux
Same code can be compiled natively, without any interpreter for OS X, Windows or Linux, using the native GUI toolkit of the OS
Pro Many integrated features
Many libraries available without additional installations : 2D & 3D, database, network, sound, xml, JSON, http...
Pro Allows to program at a lower level than most alternatives
Pro Lifetime license
Pay once, use forever.
Pro Constantly updated
Pro Supports ARM in addition to x86, AMD64 and others
Pro Can compile to plain C code
Pro Grest user community / forums with the developer very active
Cons
Con Lacks documentation
The API documentation is minimal, there's not many tutorials and the ones that are there are very small and only cover the basics. If you want to learn how to properly use it, you have to ask the community or read the source code and figure it out.
Con Not too many games to showcase it
Con Slow development rate
Con Limited free version
Free version is limited to 800 lines and can not create DLL's.
Con Some bugs are present on the Linux platform
Con Slightly bogged syntax
Sometimes the syntax bogs down, just a little with long procedure names and such. A truly minor issue.
Con Not RAD
Not a RAD environment.
