When comparing Oxygine vs PlayMaker + Unity3D, the Slant community recommends Oxygine for most people. In the question“What are the best 2D game engines?” Oxygine is ranked 18th while PlayMaker + Unity3D is ranked 77th. The most important reason people chose Oxygine is:
Most interesting is ability to build C++ Oxygine application for Web via Emscripten. So you write C++ code and it will compile it to HTML5/JS.
Specs
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Pros
Pro Games can be built as HTML5 applications
Most interesting is ability to build C++ Oxygine application for Web via Emscripten. So you write C++ code and it will compile it to HTML5/JS.
Pro Functionality can be extended with a bunch of available extenions
All of them available publicly at github.
- oxygine-movie for playing Theora movies with alpha channel
- oxygine-sound player for ogg sound/music with streaming
- oxygine-freetype library
- oxygine-billing for in-app-purchases on Android/iOS
- oxygine-spine for playing Spine animations
- oxygine-magicparticles for playing particles made with MagicParticles
Pro Will be familiar to users of ActionScript3/Flash API
If you are familiar with ActionScript3/Flash API, then you will find it easy to begin working in Oxygine. Oxygine is much like Flash in C++, as its Event Handling model is very close to that of ActionScript 3 and SceneGraph.
Pro Easy to use C++ API with optional C++11 features
Oxygine is written in C++. It provides easy to use API, which is designed with "do more with less code" philosophy. It uses a managed scenegraph system that takes care of rendering and updates, and provides ability to extend with custom rendering and updates.
Pro Free, open source and cross-platform
Oxygine is a free framework that works on OS X, Windows, Linux, iOS, Android, HTML5. It's licensed under MIT with source code available on GitHub.
Pro Robust
It's very rare to experience bugs with Oxygine.
Pro Allows playing movies with alpha channel
Using oxygine-movie extension for Oxygine you could play in your game any videos encoded with Theora codec.
You movie could have alpha channel and used as simple sprite instead of classic spreadsheet animations.
Pro Allows for flexible contol over draw processes
Pro Fast
Pro Easy to use
You'll need to put more time in learning Unity + Playmaker compared to something like GameSalad. But once get the hang of it and familiarize yourself with what it's possible to build with them, it's quite easy to use.
Pro Provides access to a huge list of assets through Asset Store
For those developers who can't afford an artist, or aren't skilled enough to create their own art, Unity features an Asset Store full of a wide variety of free and paid assets that can be easily added to your game. The Asset Store has more than just music and art. It also has code and modules that can be added to your game such as unique lighting or GUI systems.
Pro Third party plugins support
A lot of third party plugins have support for Playmaker. Playmaker team also invest time to add support for a lot of third party plugins.

Pro Elegant state-based visual scripting
Instead of a single "if this then that" event list which can become very cluttered beyond the most basic behaviors, PlayMaker gives each object a list of states where only certain events are triggered, and performing an action also changes state.
This allows for a clean, simple visual representation which helps break complex logical structures into smaller pieces, making them easier to understand.

Pro Powerful
It basically can do same things as scripting in Unity.
Cons
Con Inactive
The project does not seem to be active: there has been no new commit since mid-2019, the Twitter feed for the engine stopped posting news in 2018, and the forum is offline as of May 2021.
Con Little community support
Oxygine is a young framework. It was first released in 2013 and has yet to gather a large community. As of February 2016, the forum had just 123 members.
Con Not many tutorials available
There are not many tutorials available that teach developers on how to make a game with Oxygine from scratch. Because of this, it may be harder to pick it up or to start learning game development by using this engine.
Con Comparatively high learning curve
Although C#, JavaScript, and Boo have extensive documentation available online, it could still be difficult to wrap your head around the library and Unity's component based system.
Con Limited tutorials
There are not a lot videos with Playmaker tutorials. Official text tutorials are also quite limited. Even not every action has a description on an official wiki.
Con Performance could be better for 2D
Performance can be a real issue with 2D games. Unity 3D is actually a 3D game engine, and drags a lot of overhead with it.
For mobile, one could never achieve the performance of more specialized 2D engines with Unity3D.
