When comparing Ren'Py vs Irrlicht, the Slant community recommends Ren'Py for most people. In the question“What are the best 100% free and easy game engines for beginners?” Ren'Py is ranked 26th while Irrlicht is ranked 38th. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games
Pro Lots of examples and docs
Many working examples to study and learn. You can easily experiment modifying an example code to grok in full how the engine works. In the beginning of your learning curve, the example code will offer you many useful code snippets.

Pro Free and open source

Pro Good polymorphic design
If you are considering writing your own engine with openGL, you might want to consider Irrlicht instead. It makes many features of any engine worth its salt easy, including events, serialization, nodes, animators, materials, logging, and animation. Bring your own sound and networking.

Pro Lightweight
Especially if you compile it yourself, it can be very light in memory usage.
Pro Easy to entry level C++ experience
If you want to start game developing with C++, then Irrlicht is a good candidate since it removes most of the complications in game making in C++. It will let you obtain experience in programming and games at the same time.
Pro Support for multiple formats
This engine supports multiple formats for 3D objects and textures.
Cons
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.
Con Requires knowledge of Python to use

Con Outdated
Obsolete over 5 years ago. While the engine is being worked on with plans for new features and support, the movement is slow, leaving many engines far more advanced in certain areas.
Con Not a game engine
This is a 3D graphics engine similar to Ogre3D. Thus, it doesn't provide any pathfinding or physics support. Support for those will have to be added by the dev.
