When comparing Ren'Py vs Stride, the Slant community recommends Ren'Py for most people. In the question“What are the best game engines for point & click adventure games?” Ren'Py is ranked 7th while Stride is ranked 46th. The most important reason people chose Ren'Py is:
Available on Windows, Linux, OSX, iOS and Android.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Cross-platform
Available on Windows, Linux, OSX, iOS and Android.
Pro Active and friendly community
Pro Reasonably good at creating puzzle and point-and-click games

Pro Good looking and fast
Looking nearly as good as Unreal Engine 4, but rendering significantly faster.
Pro No royalties or licensing fees
Pro Projects are normal Visual Studio solutions
No proprietary project format, so it works with all the official .NET tooling.
Pro Supports Visual Studio
Pro Very modern render engine
Pro Powerful 3D Rendering Engine
Supports Vulkan. You can achieve good quality as in Unity3d and Unreal Engine

Pro Straightforward editor
Stride provides a simple and clean working environment for designing games.
Pro Community seems friendly and is growing
Pro Engine AND Scripting are both C#
Since the engine is written in the same language as the scripting, there is no weird mix of technologies as other engines have.
Pro Supports Vulkan
Currently the only well known open-source game engine that supports Vulkan, and probably one of the only.
Pro Easy to learn and use C#
Pro Multiple Starter Templates
The engine comes packed with multiole example projects to help you get started.
Cons
Con Not for every genre
While technically capable of creating 2D games in any genre, Ren'Py excels in creating visual novels and has a reasonable feature set for creating puzzle and point-and-click games. Other genres are best tackled by other engines.
Con Outdated Documentation and official built-in tutorials
Unfortunately, you will have to hunt relevant info on how Ren'py script works. The Ren'Py dev has the working tutorials on his Patreon, other than that you might as well just code in Python.
Con Requires knowledge of Python to use
Con No terrain editor
Unless you like working on planes, there is no terrain support.
Con Editor is Windows only
Since version 1.7, Linux can be targeted for runtime. The editor for the engine is available only to Windows though.
Con Small user community
Unity and UE have a vast amount of user community.
Con Does not currently support Playstation or Switch games
Con Iteration may be slower than with other engines due to longer "build" times when certain changes are made
Con Shader system require's overhaul
Shader's are not easy to get to grips with and Stride's shader system. Needs overhauling for easier use.
