When comparing Adventure Game Studio vs uScript + Unity3D, the Slant community recommends Adventure Game Studio for most people. In the question“What are the best 2D game engines?” Adventure Game Studio is ranked 23rd while uScript + Unity3D is ranked 97th. The most important reason people chose Adventure Game Studio is:
Good for newbie game creators. Can be used for prototyping: on several occasions was used to make a demo/experimental version before creating a final commercial product on different engine.
Specs
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Pros
Pro Easy to learn tool
Good for newbie game creators. Can be used for prototyping: on several occasions was used to make a demo/experimental version before creating a final commercial product on different engine.
Pro Completely free and open source
AGS is licensed under Artistic License 2.0 and is completely free for use for creating both freeware and commercial games.
Pro Relatively well documented
Besides the manual there are multiple text and video tutorials and code samples written by community.
Pro Used for a number of high-profile commercial releases
Adventure Game Studio has been used to develop games such as "Resonance", "Blackwell" series, "Gemini Rue", "Primordia".
Pro Lots of assets available
An extensive library of game templates and script modules accumulated over years. You can construct a simple game in hours (if you know what you are doing).
Pro Friendly community
An old, big and active community which would support newcomers not only in learning basics of the engine, but can help with every aspect of game making (including art, voice acting, moral support, etc).

Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.

Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.

Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Cons
Con Natively supports only 2D
2D only native support, 3D could be supported with plugins though.
Con Uses dated tech
Engine is based on the old technologies, which impose number of limitations and may cause problems on latest systems (level of annoyance varies depending on your priorities).
Con Graphics renderer is a bit dated
Graphics renderer is not well optimized for high-resolution games and complex effects.
Con No visual editor for scripts
You have to actually write all scripts yourself.
Con Development is slow
Further development of the engine is currently slow, done by only few people in their free time.
Con AGS Script isn't as full-featured as other scripting languages
Its own scripting language has lower syntax capabilities compared to modern script languages.
Con Assets cover almost exclusively adventure/quest genre
The features, script functions and game templates are very biased towards adventure/quest genre. The non-adventure games were made in AGS (2D shooters, platformers, turn-based strategies), but their development usually requires to write everything from scratch.
Con Workflow is closely coupled with the editor
Workflow is very tied to the editor and custom file formats, which can cause problems for bigger, more professional projects (interfering with source control, parallel development, automated builds, etc)

Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.
