When comparing CRM32Pro SDK vs Pixi.js, the Slant community recommends Pixi.js for most people. In the question“What are the best 2D game engines?” Pixi.js is ranked 56th while CRM32Pro SDK is ranked 91st. The most important reason people chose Pixi.js is:
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
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Pros

Pro Great tools included
EditorDPF: resource editor for managing images, tiles, sprites, sounds, etc. of your game
MSTE: tile-based parallax scrolling engine with support to Tiled Qt .TMX files
SetupProject: customized configuration system.

Pro Cross-platform
CRM32Pro works on Windows, Linux and MacOS X.

Pro Open source and free
CRM32Pro is licensed under LGPL license with full access to the source code on the website.
Pro Supports WebGL w/ canvas fallback
Pixi is a WebGL renderer, but can fall back to canvas if WebGL is not supported or turned off.
Pro Will be familiar to ActionScript developers
Pixi.js uses a code structure that's very similar to ActionScript.
Cons
Con Not as beginner friendly
C/C++ skills and general knowledge of SDL and basic game programming is required in order to get all the benefits.
Con Not a complete solution
Pixi only provides the renderer.
