When comparing Leadwerks Game Engine vs Twine, the Slant community recommends Twine for most people. In the question“What are the best 2D game engines?” Twine is ranked 38th while Leadwerks Game Engine is ranked 76th. The most important reason people chose Twine is:
The basics are very easy to grasp, and you can have a basic story up in minutes.
Specs
Ranked in these QuestionsQuestion Ranking
Pros

Pro Versatile flow diagram script model
Leadwerks's flowgraphs resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.
Pro Built-in level editor
Has an acceptable 3D map editor that is easy to use.
Pro Handful of Prefabs and Scripts
For example, you take a model (e.g. torch), add a light source to it, add a particle generator (for fire) and save it as a prefab (one file). Then this prefab can be used to add many torches with fire and light.
Pro Easy to understand
The basics are very easy to grasp, and you can have a basic story up in minutes.
Pro Free for commercial projects
Twine is based on a GPL licence. You are free to download, modify and publish derivatives - even commercially.
Cons
Con Very buggy
Leadworks is a not complete, it's a work in progress. As such many parts of the engine are clunky, especially the level editor.

Con Documentation and support are limited for non-coders
The flowgraph editor can be used with free script assets to build games without writing any code, but this is not directly intended or encouraged by Leadwerks.
Con Highly misleading advertising
Con Limited to interactive fiction
Twine is specialized to decision-based interactive fiction. Under the hood, a Twine game is just a flowchart for page transitions; the only way to add more complex behavior is to code it from scratch in JavaScript.
