When comparing Defold vs Unity 2D, the Slant community recommends Unity 2D for most people. In the question“What are the best 2D game engines?” Unity 2D is ranked 7th while Defold is ranked 21st. The most important reason people chose Unity 2D is:
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Easy to learn
Defold uses Lua, which is regarded as an easy to learn language by most.
Pro Completely free of charge
Software and online dashboard are free of charge.
Pro Good combination of visual editing + code (Lua)
You can do a lot with drag and drop, but you're not limited -- the code (Lua, which is easy to learn) allows you more power than just visual editing usually gives you.
Pro Fast results
Going from idea to result is very important for the creative process.
Pro Visual editor
Pro Very performant
Being crossplatform it is important to work on low end devices.
Pro Easy and fast export for various platforms
Pro Great community
A very active and friendly community in forums.
Pro Source code available
You can download and modify the source code of the Editor and the engine for free.
Pro Collaborative
You can invite friends from the dashboard and create games together.
Pro Hot reload
It allows you to change scripts in a game while it is running live. Common use-cases is to tweak gameplay parameters or to perform debugging on a running game.
Pro Built into Unity 4.3+
2D game creation was a major feature request from the Unity community and was added with version 4.3. 2D is provided in both the Pro and Free distribution of Unity.
Pro Integrates with Mecanim
Mecanim brings state machines and blending to 2D bone animation. The state machine editor allows for designers and programmers to visually create a Finite State Machine (FSM) to control when animations should play. Mecanim also allows for blending so an animation can transition smoothly between two states without the need of in between frames made by an animator.
Pro Sprite Sheet and Bone based animation supported
Both types of 2D animation for game development are supported in Unity’s system and can be used interchangeably in the timeline.
Pro Easily change sprites dynamically
Usually used for character customization, programmers can change any sprite in a bone animation at runtime easily by referencing the bone and loading the new sprite from the resources folder.
Cons
Con Lacks critical features
- Vertices can't be animated, so you can't have ANY organic feel (like... lungs breathing).
- Parent bone can't be animated without affecting the children. This is especially impeding for organic feel, again.
- No option to show & unshow assets (or it is hidden), like for switching weapon on your character for exemple.

Con Poor script interface for texture atlases
Accessing individual sprites within an atlas texture is possible at runtime, but requires use of the Resources folder subsystem.
