When comparing Defold vs uScript + Unity3D, the Slant community recommends Defold for most people. In the question“What are the best 2D game engines?” Defold is ranked 19th while uScript + Unity3D is ranked 97th. The most important reason people chose Defold is:
Defold uses Lua, which is regarded as an easy to learn language by most.
Specs
Ranked in these QuestionsQuestion Ranking
Pros
Pro Easy to learn
Defold uses Lua, which is regarded as an easy to learn language by most.
Pro Completely free of charge
Software and online dashboard are free of charge.
Pro Good combination of visual editing + code (Lua)
You can do a lot with drag and drop, but you're not limited -- the code (Lua, which is easy to learn) allows you more power than just visual editing usually gives you.
Pro Fast results
Going from idea to result is very important for the creative process.
Pro Visual editor
Pro Very performant
Being crossplatform it is important to work on low end devices.
Pro Easy and fast export for various platforms
Pro Great community
A very active and friendly community in forums.
Pro Source code available
You can download and modify the source code of the Editor and the engine for free.
Pro Collaborative
You can invite friends from the dashboard and create games together.
Pro Hot reload
It allows you to change scripts in a game while it is running live. Common use-cases is to tweak gameplay parameters or to perform debugging on a running game.

Pro Automatically generates nodes for third-party script assets
uScript's nodes are a visual representation of actual code blocks, and it takes advantage of C#'s reflection capabilities to automatically create nodes for any scripts it finds in your project, regardless of the source. This makes it inherently compatible with pretty much everything.
Custom nodes can also be created by hand, for cases where the automatically created ones contain more elements than they actually need.

Pro Versatile flow diagram script model
Modeled after UDK's Kismet (the predecessor to UE4's Blueprint), uScript's scripts resemble flowcharts where each box represents a function or value, with connections between them representing program flow. This provides a better at-a-glance indication of game logic than a simple list of events, and makes complex behaviors easier to accomplish.

Pro Generates C# source code
Nodes are translated directly to C# files in your project. This is great for learning to code, and also for advanced users who can use uScript for fast prototyping and then further optimize the scripts if necessary.
Cons

Con Not that easy to use
It's a lot more complicated compared to something like Playmaker. Same tasks take a lot more time.
