When comparing Nix vs SliTaz, the Slant community recommends SliTaz for most people. In the question“What are the best Linux distributions for desktops?” SliTaz is ranked 27th while Nix is ranked 75th. The most important reason people chose SliTaz is:
The core liveCD is only 35 megabytes. The boot-from-internet option fits on a floppy.
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Pros
Pro No side effects when building packages
Nix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Isolated development environments
Nix allows the creation of project-specific shell and build environments which are isolated from the rest of the system. These environments are defined declaratively to ensure reproducibility.
Pro Can replace docker in some places
Pro Can use multiple versions of the same package
Because of the functional approach it takes, Nix makes it easy for systems to use multiple versions of the same package simultaneously, and ensure that updating or removing a package can't break other packages.
Pro The configuration works on "All machines"
No more of the traditional: "it works on my machine". When it says reproducible, this is the real deal.
Pro One of the smallest distributions with desktop GUI
The core liveCD is only 35 megabytes. The boot-from-internet option fits on a floppy.
Pro Very fast
Pro Can add desktop effects
SliTaz has a feature called "Desktop Effects" which can add shadow or fade effects to windows.
Pro Very customizable
SliTaz is very customizable. You can programatically edit and change anything you want on how the OS looks or behaves.
Cons
Con Does not work well for services on non-NixOS systems
When using Nix with anything other than NixOS you can run into difficulties with trying to start up services. For example, you can install docker with Nix, but it won't integrate with the host system's systemd leaving you to handcraft awkward workarounds in order to start the background service that docker requires. This seems like a critical flaw when using Nix on anything that is not NixOS, and it's unfortunate because this affects many of the packages many users would be most interested in using Nix to handle.
Con Steep learning curve
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Nix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions. Especially in Debian/Ubuntu it can cause severe problems where the upgrade process blocks and the user needs to resolve the 3-way merge.
Con Feels slightly over-complicated
Con Install instructions are in French
When first booting SliTaz from a USB or from a Live CD, the installation instructions are in French.
Con Not much variety as to available applications
SliTaz does not have as many applications in its repositories as the bigger distros such as Ubuntu.