When comparing GNU Guix vs Artix Linux, the Slant community recommends Artix Linux for most people. In the question“What are the best Linux distributions for desktops?” Artix Linux is ranked 2nd while GNU Guix is ranked 81st.
Ranked in these QuestionsQuestion Ranking
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro No systemd
Artix actively supports the runit init system known from Void Linux. (Equally besides the OpenRC init system known from Gentoo).
Only the software you would need like Terminal emulator, file manager, media player and a browser.
Pro Compatible with Arch Repositories
It is fully compatible with almost all packages from community, extra, multilib and AUR.
Pro Close to bare Arch Linux
No learning curve if you're coming from Arch or any of its derivatives.
Pro Rolling distro
You can have a functional system in less than 10 mins using GUI installer OR you can do it "the Arch way".
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con No systemd
Some packages flat out won't work because systemd is non existent, sadly pipewire needs systemd to run. Hopefully Pipewire becomes usable soon. Edit: Pipewire does work but you will have to make a startup script.
Con Few Arch packages might not be available yet
Developers are working migrating all packages into their own repositories while ensuring there's no systemd malware.