When comparing GNU Guix vs MX Linux, the Slant community recommends MX Linux for most people. In the question“What are the best Linux distributions for desktops?” MX Linux is ranked 13th while GNU Guix is ranked 58th.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro Easy to use
Pro Supports non-free drivers
Pro MX Snapshot: lets you make your own distro
Can create your own ISO (snapshot) and use it either as live-session and install back when needed.
With the (pre-installed) Snapshot tool you can easily create an ISO of your running system and then save it to a USB (or other media) and use "your own" distro as a live session or install back whenever you like (even on a different PC with different specs with no issues). You can even give that customized ISO to friends (selecting "non-personal" ISO when creating the snapshot; thus resetting the accounts & passwords and Home folder etc.).
Also you can save that ISO directly encrypted via MX Live USB Maker tool. Again, you can install MX encrypted during installation with just ticking a box, no matter if it's the official ISO or your snapshot.
Pro Good MX Tools and Package Installer
MX Linux comes with its own set of tools called MX Tools, designed to make life easier for users.
Pro Easy install
Pro Based on Debian
It is based on Debian and not based on Ubuntu.
Pro Lightweight
Pro Very stable
Pro No systemd
Pro Can also be used as an emergency tool
It has almost all tools to repair non booting systems or recover files & folders and save them on a safe place. And when thought together with it starts quick on live-session. In addition, you can do these with "your own", customized distro (snapshot).
Pro Live-Session boots fastest after Puppy
After Puppy Linux (which's aimed to run from RAM and which is smaller in size) the second fastest (head & shoulders) booting one (together with the sister project antiX) and also has the option "toram" to run from RAM. Yes, not only when compared to full distros, even far faster than small sized or tiny distros, especially when booted to "live-session", about 2 - 2.5 times faster on an old single core laptop.
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Only one Desktop Environment
Con Its XFCE version is too laggy
XFCE is meant to be lightweight, and it's almost true for other XFCE distros but not for MX Linux.
Con Old software
Many software applications are older.
Con Remixed Debian testing
It's mainly a Debian stable with some recompiled/backported Debian testing packages.
Con Includes non-free drivers
Con More than 50 tweaking softwares pre-installed
Con Longer boot time
Con 10s of media players preinstalled
Con Too much preinstalled applications
Con Causes overheating on some hardwares
Other debian based XFCE distros- Xubuntu, Debian XFCE, Devuan leave small footprint on system whereas MXLinux uses too much CPU resources on same system.
Con Installer and configuration tools are different
Installer and configuration tools are different and can take some time getting used to.
Con Too much customization
