When comparing GNU Guix vs Linux From Scratch, the Slant community recommends GNU Guix for most people. In the question“What are the best Linux distributions for desktops?” GNU Guix is ranked 58th while Linux From Scratch is ranked 63rd. The most important reason people chose GNU Guix is:
A method which works across languages and provides a reproducible programming environment.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro Best for learning the components, libraries and configurations of the whole system one-by-one
It is an opportunity for the learner to learn what's behind every piece of program in the system, because you will install and configure all the packages manually. It is also as an advantage to expand your knowledge by searching the possibilities of crafting your unique flavor, for example your own package manager and update schemes.
Pro For those who wonder what it takes to create an actual Linux distribution
It's a very useful learning experience; showing the user what is required and in what order, to obtain a running Linux system - from the inside out.
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Not recommended for Beginners
By creating a Linux system from scratch you will be managing and compiling all of the systems packages by hand, so advanced Linux knowledge is recommended.
Con Takes a while to create the system. Only for those people who would like to create their very own distribution, or just to understand what makes a Linux system tick.
Linux From Scratch, requires the user to download and compile, all the various required system libraries and programs in a ch-rooted environment. This is usually done from within an existing and already running Linux system. This is not really a con, just a note to the new user.