When comparing GNU Guix vs Pop!_OS, the Slant community recommends Pop!_OS for most people. In the question“What are the best Linux distributions for desktops?” Pop!_OS is ranked 16th while GNU Guix is ranked 58th. The most important reason people chose Pop!_OS is:
If you're a fan of flat desktop interfaces reminiscent of Material design on Android, you'll like the theme that comes as a default in Pop! OS. The desktop and title bars all use a bright turquoise theme that makes the interface feel happy and borderline retro-chic. I found it to be like something you'd find printed on a ringer t-shirt.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro Pop! makes GNOME look really good
If you're a fan of flat desktop interfaces reminiscent of Material design on Android, you'll like the theme that comes as a default in Pop! OS. The desktop and title bars all use a bright turquoise theme that makes the interface feel happy and borderline retro-chic. I found it to be like something you'd find printed on a ringer t-shirt.
Pro User-friendly installer
The visually appealing and easy to use installer makes dual booting as easy as it can be.
Pro Nice gnome theme dy default
Has nice gnome theme looks really good.
Pro Ready to play games, out of the box
If you still miss how easy it was to just click-install and play games in Windows, Pop! will give you that similar expectation.
Pro A separate NVIDIA version
Most linux distros seem to hate Nvidia's graphics cards e.g. Fedora and OpenSUSE. System76 have decided to be kind. They have decided to form a good relationship with Nvidia fans and Nvidia itself. By creating a separate installation media that is dedicated for providing support to Nvidia's graphics cards. Even going as far as putting Nvidia's driver updates on Pop!_Shop for users to easily access and install.
Pro Optimized for modern hardware
Whereas normally, to use a brand new computer with a Linux OS, you would typically try to use unstable and sometimes buggy drivers - or struggle without hardware support until a stable release comes along.
Pro Made by a hardware seller
System76 is a hardware company. It configures machines to ship with Linux pre-installed. This means its entire business model centers around delivering a quality desktop Linux experience.
As a result, the company pours more attention onto the desktop. It can fix visual issues and may be able to provide a smoother overall experience than you would have installing a different version of Linux on your machine yourself. Providing Pop!_OS also empowers System76 to make certain fixes for users directly rather than having to coordinate with Canonical or the broader Ubuntu community.
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con 64-bit only
Some older PCs still have 32 Bit processors. This limitation will be a major con for those who use an older PC since they will not be able to install, run it in a VM or live media