When comparing GNU Guix vs OpenSUSE, the Slant community recommends OpenSUSE for most people. In the question“What are the best Linux distributions for desktops?” OpenSUSE is ranked 14th while GNU Guix is ranked 58th. The most important reason people chose OpenSUSE is:
The packaging team is dependable resulting in system updates that come in a timely fashion and systems which rarely, if ever, break due to packaging. The versions of software that are selected and the configuration of them is typically extremely high quality.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.

Pro Extremely reliable
The packaging team is dependable resulting in system updates that come in a timely fashion and systems which rarely, if ever, break due to packaging. The versions of software that are selected and the configuration of them is typically extremely high quality.
Pro Easy installation and administration
openSUSE makes use of a GUI tool called YaST to install and setup an openSUSE system.
YaST is very easy to use and makes the process of installing and maintaining an openSUSE installation a breeze.
Pro Easily get packages from other sources
SUSE Build Service offers packages from the same sources as Fedora, Debian, Ubuntu, SUSE Linux Enterprise and other distributions. This is the most underused package tool in Linux today.
Pro Probably the best KDE desktop experience
Both Gnome and KDE desktop options are well polished to fit with the opensuse theme and environement, so either desktop is a great choice.
Pro Very stable
Stable, reliable, rock solid.
Pro Amazing choice for both newbies and power users
OpenSUSE is very easy in terms of installing packages, administration and customization, yet very powerful in the same. Every user should find his own piece of cake in this OS.
Pro Supports RPM packages
Popular format shared with distros like Fedora, RHEL, Scientific Linux, Mageia etc.
Pro Built-in drivers
Does the job needed and has the hardware drivers for the application built-in by the H/W supplier.
Pro Dedicated professional community
Directions on other desktop Linux's often force you to use GUI packages or have steps that introduce security issues.
OpenSUSE has a professional community and directions are usually geared toward GUI and CLI with similar steps.
Pro Feature rich
It comes standard with a large number of pre-added applications that sort out your day-to-day use.
Pro "Tumbleweed" Rolling Release
Regular and easy upgrades to stable and well tested software.
Pro YaST
Best administration and setup tool.
Pro One-Click install
Much better system then other distros for installing any package. It is as simple as clicking on one button and typing in your password. Adds a repo to your system keeping everything updated at the same time.
Pro Fast
Applications feel fast.
Pro Convenient package management with Zypper
Fast, reliable, powerful and almost impossible to leave a broken system.
The Yast interface will also give you access to a Zypper GUI if you are uncomfortable with the command line.
Pro Outstanding community support
OpenSUSE has a VERY active user community. Questions on forums are generally answered in minutes.
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Some clear differences from other Linux distros
This might be a systemd issue or OpenSUSE specific, but changing certain text files does not update things. They must be edited in YaST, or in /etc/sysconfig/
Con Old kernel by the Leap version
Kernel in Leap 42.3 is in version 4.4, that's pretty old.
Con Poor support for nVidia drivers in Tumbleweed
No native driver support and nouveau may be broken, especially for KDE, and not suitable for some GPUs.
Con Bloated and slow
Con Short lived distro
Every release lasts 18 months only before needing a major upgrade.
Con Updates
Not a huge problem, but Tumbleweed is better updated via the command line.
Con Massive ISO download
The base ISOs are over 4 gigs, so be prepared for a very long DL if you have slow internet. There's a network installer version, but that just delays the long DL.
Con Bad support to NTFS fotmat.
Con Limited community support
The community is fairly small, and there is no indication on the forums regarding when a issues will be solved.
Con Packman repository has to be added to have good software support
Con Startup takes a long time
Con Updates
Not a huge problem, but Tubleweed is better updated via the command line.
Con Complex permissions policy
