When comparing GNU Guix vs NixOS, the Slant community recommends NixOS for most people. In the question“What are the best Linux distributions for desktops?” NixOS is ranked 19th while GNU Guix is ranked 58th. The most important reason people chose NixOS is:
Atomic non-destructive upgrades / rollback of a system upgrade / declarative reproducible system configuration / unprivileged installation of packages / transparent source or binary deployment.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro State of the art package manager
Atomic non-destructive upgrades / rollback of a system upgrade / declarative reproducible system configuration / unprivileged installation of packages / transparent source or binary deployment.
Pro Minimal
You can start with a minimal environment and add packages and software to suit your needs as you go along.
Pro Reproducible system
NixOS is configured using the Nix package manager, allowing your system to be replicated and kept in sync across multiple machines. Great for keeping a laptop and desktop in sync.
Pro Robust
Packages don't break after a NixOS upgrade as they are prone to with other distros (especially Arch).
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Documentation is not good
A lot of the documentation of various functions is buried on the source code, their respective manuals, or non-existent. The documentation, the conventions, and the scattered toolchain really made searching for stuff easily missable.