When comparing GNU Guix vs PCLinuxOS, the Slant community recommends PCLinuxOS for most people. In the question“What are the best Linux distributions for desktops?” PCLinuxOS is ranked 38th while GNU Guix is ranked 58th. The most important reason people chose PCLinuxOS is:
The distribution is continually updated, so there's no need to install OS upgrades by hand.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro Rolling release
The distribution is continually updated, so there's no need to install OS upgrades by hand.
Pro Stable
PCLinuxOS is designed around stability.
Pro Multiple desktops available
Mate, LXDE, and KDE desktops are available.
Pro Can remaster the boot DVD
PCLinuxOS has built in tools for remastering bootable DVD into a copy of current install.
Pro Excellent hardware compatibility
Comes with nVidia drivers out of the box. Important if the PC has an nVidia chipset. Most Debian based distros don't have nVidia drivers available at install time.
LXDE version works well with older hardware.
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Installation fails most of the time, error messages, and hard to go to full screen in virtual box
Con Uses RPM packaging system
Uses the RPM packaging system with APT, rather than the more popular DEB packages.