When comparing GNU Guix vs Parabola GNU/Linux-libre, the Slant community recommends Parabola GNU/Linux-libre for most people. In the question“What are the best Linux distributions for desktops?” Parabola GNU/Linux-libre is ranked 24th while GNU Guix is ranked 81st.
Ranked in these QuestionsQuestion Ranking
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro Protects your freedom, certified free by the FSF
Pro Option to use OpenRC or Systemd
Parabola has an OpenRC edition and a Systemd edition, so users can choose which init system they want.
Pro All the benefits of Arch Linux, only 100% certified free software
Pro Very Secure
Pro Has its own repos
Parabola has its own repos (which are almost as large as Arch Linux) and the IceCat browser is included.
Pro Can be migrated from Arch Linux without a CD/USB
Pro Based on Arch Linux
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Won't work out-of-the-box on the most PC's
Almost all PCs need non-free drivers but Parabola has none to offer.
Con Not compatible with AUR
Unlike other Arch-based distros, this free distro doesn't support AUR.
Con Small repositories
Since Parabola is a completely free distro, there is no non-free software available and the community repositories are small compared to the AUR.
Con Incompetent developers
They only care about removing "non-free" software, rather than making a properly working OS.
Con Same cons that apply to Arch Linux
Con Serves no purpose
It's just Arch without non-free software and is basically a niche OS with few users.
Con Not really free
People have to pay hundreds to maintain this distro.