When comparing GNU Guix vs Docker, the Slant community recommends Docker for most people. In the question“What are the best Linux package managers?” Docker is ranked 11th while GNU Guix is ranked 12th. The most important reason people chose Docker is:
Docker creates a single object, containing an application with its dependencies, that can be moved between any docker-enabled machines, guaranteeing the same environment for application execution.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro Allows for portable application deployment
Docker creates a single object, containing an application with its dependencies, that can be moved between any docker-enabled machines, guaranteeing the same environment for application execution.
Pro Git-like capabilities
Docker tracks changes in systems. It allows for commits and rollbacks and for quick deployment due to having to deploy only the updated code.
Pro Allows re-using components
Docker essentially allows creating boilerplate systems (a LAMP stack, for example) that can be used as a starting point on multiple projects. And you can find multiple such containers already created by people in their public registry.
Pro Automatic build
Allows automatically assembling a container from its source code.
Pro Provides easy sharing and installation of containers through a public registry
Docker allows easily pushing and pulling containers to and from their public index.docker.io registry. Additionally, dotCloud maintains a list of official repositories of the more popular containers.
Pro Application-centric
Pro Works in virtualized environments
You can set up Docker within an already virtualized environment such as a virtual machine. This allows you to run Docker on Mac and Windows, among other use-cases.
Pro Low overhead
Pro Supports a wide range of isolation tools
Docker can be used with OpenVZ, systemd-nspawn, libvirt-lxc, libvirt-sandbox, qemu/kvm, BSD Jails, Solaris Zones, and chroot.
Pro Tool ecosystem
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Large image size
Con Security concerns
Con Kernel OS fragmentation
