When comparing GNU Guix vs TinyCore, the Slant community recommends TinyCore for most people. In the question“What are the best Linux distributions for desktops?” TinyCore is ranked 39th while GNU Guix is ranked 81st. The most important reason people chose TinyCore is:
Can be as small as about 9MB, and with even X, wireless modules, and more, it takes up only 72MB.
Specs
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Pros
Pro Can setup a shell which has exactly the defined libraries available
A method which works across languages and provides a reproducible programming environment.
Pro Can always roll back to a safe state
Guix creates new profile generations for each operation. If anything goes wrong, a simple --roll-back gets you immediately back to the previous, working, generation. Because it is a purely functional package management system, generations don't affect each other, so you're back to the exact same state as before : still working.
Pro Can create independent packages
Guix pack creates packages which do not need Guix to be run.
Pro No side effects when building packages
Guix is a purely functional package management system. This means that the act of building a package does not have side effects, such as destructively updating or deleting files that may be used by other packages.
Pro Can build containers right-away, from docker to tarballs
See guix pack --help and here.
Pro Easy to add your own packages
The clean and declarative syntax makes it easy to define new packages by using an existing one as an example.
Pro Doesn't require root privileges
Normal users can install packages on a Guix-enabled system, or even run their own Guix instance if the system isn't Guix-enabled.
Pro VERY small
Can be as small as about 9MB, and with even X, wireless modules, and more, it takes up only 72MB.
Pro Surprisingly customizable
Fluxbox window manager is especially slick looking all considered, and the options one gets with it's toolbar, app bar, and wallpaper are surprisingly complex for such a small distro.
Pro Use of tcz packages stored on media outside of MyData
Cons
Con Updates take a long time
It's gotten better over time but both updating Guix itself and updating the installed packages can take a long time.
Con Cannot handle filetypes that have different semantics across different versions
While the functional approach that Guix takes is great for sandboxing binary artifacts of packages, it seriously lacks any power in handling configuration files or user data. It's difficult to upgrade and downgrade files where semantics and syntax can change between versions.
Con Not visually appealing
The operating system is not very pretty.
Con Can be somewhat slow to turn on
Once it is up and going it is unrivaled in speed, but it can be sluggish when it comes to turning on, restarting, or turning off.
