When comparing Paranoia vs D6 Space, the Slant community recommends Paranoia for most people. In the question“What are the best sci fi-themed tabletop RPGs?” Paranoia is ranked 4th while D6 Space is ranked 13th. The most important reason people chose Paranoia is:
Paranoia offers a different experience to a typical roleplaying game, and tends to lead to characters suffering multiple deaths (they have 6 clones = 'lives'). While it doesn't lend itself well to long campaigns, it has a tight scenario-design formula, which makes running games off the cuff quite easy for the referee. Players don't normally need much encouragement to get into the spirit of the game - making it ideal for a short notice, one shot game.
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Pros
Pro Perfect for One Shots.
Paranoia offers a different experience to a typical roleplaying game, and tends to lead to characters suffering multiple deaths (they have 6 clones = 'lives'). While it doesn't lend itself well to long campaigns, it has a tight scenario-design formula, which makes running games off the cuff quite easy for the referee. Players don't normally need much encouragement to get into the spirit of the game - making it ideal for a short notice, one shot game.
Pro Humourous in tone
There is a lot of tongue in cheek and black humour in this dystopian setting.
Pro Semi-competitive play
Secretively backstabbing other players is encouraged, setting it apart from many of its peers.
Pro No special dice required
The game can be played with common six-sided dice.
Pro Free to download
This is old (but still great) system used for the original Star Wars RPG. So although it's a free download it's an excellent, mature system.