When comparing Little Snitch vs One Periodic' s Hands Off, the Slant community recommends Little Snitch for most people. In the question“What is the best OS X firewall?” Little Snitch is ranked 2nd while One Periodic' s Hands Off is ranked 4th. The most important reason people chose Little Snitch is:
Little Snitch rules work even at login screen. Even when receiving attempted connection alerts, once logged in LS has stopped and requested permission for them.
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Pros
Pro Protected even at login screen
Little Snitch rules work even at login screen. Even when receiving attempted connection alerts, once logged in LS has stopped and requested permission for them.
Pro Comparatively easy to use
Easier to use than traditional firewall software, but more powerful due to design and workflow.
Pro Protects your privacy
Protects your privacy and helps to prevent unwanted connections.
Pro It lets you control application's disk writing permissions as well
Besides giving you control over what applications in your computer can access the internet, it also lets you select which ones are allowed to write to your disk, so if you're very paranoid about data leaking, this app is for you.
Pro Prevents applications from phoning home
It can block both incoming and outgoing connections.
Pro User friendly interface
It resolves DNS queries, so instead of popping up with a generic question like "I wan to to connect to 17.173.255.222 on UDP port 16384", a more informative popup will tell you "I want to connect to talk.google.com".
Cons
Con Expensive
It's expensive when compared to other firewall software out there.