Here’s the Deal
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When comparing Material Design Lite vs Skeleton, the Slant community recommends Skeleton for most people. In the question“What is the best CSS framework?” Skeleton is ranked 6th while Material Design Lite is ranked 12th.
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Pros
Pro Developed by Google
Material Design Lite is a framework created by Google, who are also responsible for the creation of Material Design.
Pro Very customizable
Pro Lightweight
Pro Responsive grid
Pro Style agnostic
Pro Vanilla CSS
No bells and whistles for Skeleton, it's just CSS.
Pro Media queries
Cons
Con Deprecated
No longer maintained
Con On limited support
Google moved further development efforts to Material Components for the web.
Con Not maintained anymore
No active development for two years.